Erecgel (Sildenafil Citrate Topical Gel)
Sildenafil is indicated for the treatment of erectile dysfunction and impotence in men and sexual arousal disorder in women. Sildenafil makes smooth muscle relax and blood flow into the corpus cavernosum, produces an erection in men and sexual arousal in women. Sildenafil inhibits cell cycle type 2 phosphodiesterase (cGMP) and increases nitric oxide (NO) in cells. This enzyme regulates blood flow to the penis. In fact, sildenafil increases blood flow to the penis during sexual stimulation.
Since sildenafil is also involved in increasing blood supply to the vagina and clitoral area, it can improve irritation and orgasm in women. Women’s sexual arousal disorder occurs when increased blood flow is not sufficient for sexual activity. Arousal disorder is usually associated with orgasmic disorder.
Evidence also suggests that sildenafil increases uterine blood flow and increases endometrial thickness. Because of this feature, it is a potential choice for improving thin endometrial, which reduces fertilization and pregnancy rates in women. Low thickness of endometrial is one reason for the failure of infertility treatment methods, especially IVF.
Onset of action is within 30 minutes after administration.
Duration of action is up to 4 hours but with less response than that seen at 2 hours.
Dosing and administration:
The exact amount of medicine should be prescribed by your doctor. However usual adult dosing is mentioned as follow:
Erectile dysfunction in men: Apply a thin layer on the glans penis half an hour before intimacy.
Sexual arousal disorder in women: Apply a thin layer on the clitoral area half an hour before intimacy.
Geriatric patients: Use the drug under supervision of your physician.
Sildenafil is contraindicated in combination with nitrates, including Nitroglycerin, Isosorbide dinitrate.
Sildenafil Gel Benefits:
1) Due to direct contact with the target position and rapid absorption through the skin, it is more effective.
2) Due to the solubility of the gel in water, it is easily wiped off the skin.
3) The dose of the drug is lower than that of the oral drug because of the greater effect of the gel.
4) The topical effect of sildenafil gel is fast and with minimal side effects.